Executive Director, Head of Global Site Management

Role Summary

The Head of Global Site Management leads all site-facing clinical trial activities across the global development portfolio.  This operational leadership role is responsible for Site Management & Monitoring and Clinical Trial Optimization & Strategic Partnership functions.  This role provides strategic leadership for site start-up, site management, and monitoring to drive predictable execution, accelerate timelines, improve enrollment performance, ensure high-quality data, and establish strategic site partnerships.

As a member of the Clinical Operations senior leadership team, this role is also responsible for supporting strategic initiatives across the development organization.

This is a 4 day onsite position - M-Th

Key Responsibilities

Build & lead global site management, monitoring, and study start-up activities across all clinical programs

Develop and execute site strategies to optimize selection, activation, enrollment, and retention

Establish consistent monitoring models, including risk-based monitoring approaches

Build and maintain strategic relationships with investigative sites, site networks, and partners

Partner closely with Clinical Operations, Clinical Development, Biometrics, and Development Services to ensure seamless, disciplined program and trial execution

Identify and mitigate site-level operational and quality risks

Establish scalable processes, metrics, and dashboards to track and improve site performance

Establish operating model inclusive of vendor strategy, oversight, risk management, key performance metrics, and dashboards

Provide expert insight into operational strategy plans (feasibility, monitoring strategies) and operating budgets

Create and continuously improve standard operating procedures, work instructions, to ensure inspection readiness

Participate in regulatory authority inspections, sponsor audits, and oversee site audits in partnership with Quality

Ensure compliance with GCP, regulatory requirements, and internal standards

Ability to assess and transform capabilities through AI and Automation solutions or strategies

Up to 20-30% domestic and international travel, as required.

Qualifications

Bachelor's degree in life sciences or related field

12+ years of experience in site management or clinical operations leadership

Or advanced degree (PhD, MBA, Masters) and 10+ yrs of experience

Deep expertise in global study start-up and enrollment optimization

Strong people leadership and stakeholder management skills